FELINE CHRONIC GINGIVOSTOMATITIS (FCGS) STUDY
Hope for cats with no alternative options
This is potentially the first drug targeting the disease process
Cats with refractory chronic gingivostomatitis suffer with pain and loss of quality of life due to persistent oral inflammatory lesions despite medical therapy and extraction of their teeth. This often results in a myriad of clinical signs including:
• Licking excessively
• Drooling
• Not wanting to groom
• Vocalization
• Bleeding gums
• Sores in the mouth
Current Clinical Trial
There is currently a pivotal clinical field trial being conducted to establish reasonable expectation of effectiveness and to evaluate clinical safety in cats with refractory chronic gingivostomatitis. The study is evaluating adult mesenchymal stem cells which have been shown to improve oral lesions, inflammation, and quality of life in these cats1-3.
Why Stem Cells?
Stem cells are naturally occurring cells that exist in adult tissues and have regenerative properties (help tissues repair and heal). They have the ability to modify the immune system and target the underlying disease process.
The stem cells used in this investigational product are derived from a healthy donor cat’s uterus that is collected during a routine spay procedure. Rather than the uterus being discarded as normal after surgery, it is packaged in a sterile manner and shipped to the manufacturing facility. The donor cat recovery follows a normal spay procedure.
The mesenchymal stem cells are harvested, cultured, expanded, and frozen at ultra cold temperatures to provide a source of live cells once thawed at the time of treatment. These stem cells have the ability to immunomodulate (regulation of the immune system to be adaptive) through cellular signaling. This provides a natural and targeted mechanism for the treatment of disease.